Background: The most commonly diagnosed type of cancer is breast cancer., The aim of this study is to evaluate posture deviations in women after mastectomy based on the surgically treated side. Methods: This study was conducted between November 2022 to May 2023. Forty-two female participants aging from 40-60 years were suffering from Breast cancer and had gone on Mastectomy surgery. All patients were assessed before and after surgery. The first evaluation was done before mastectomy and the second assessment was done 3 months after mastectomy. Results: Showed that in lateral translation variables, there was significant increase in Head and Shoulders variables after mastectomy and no significant increase in Hip/Pelvis variable after mastectomy. While in anterior translation variables, there was significant increase in Head, Shoulders, and Hip/Pelvic variables after intervention). Conclusion: according to the results of the study, it can be concluded that Posture Screen Mobile® could measure postural deviations post mastectomy