Introduction: Diabetic patients are subjected to many events that could have a considerable influence on their quality of life. Therefore, measuring health-related quality of life (HRQoL) in Type 2 diabetic patients is essential as one of the objectives of the healthcare services. To assess the quality of life of type 2 diabetic patients in Saudi Arabia. Methods: A descriptive cross-sectional study was done among a representative sample of adult diabetic type 2 patients attending diabetes center in Saudi Arabia in North Western part in Saudi Arabia. A self-administered questionnaire composed of three main sections was utilized; Socio demographic data, clinical data and the Arabic version of the Short-Form 36-item survey (SF-36) to assess the health-related quality of life (HRQOL). Results: The study included 235 type 2 diabetic patients, out of targeted 243, with a response rate of 96.7%. Females represented 51.1% of them. Their age ranged between 20 and 76 years with an arithmetic mean of 42.5 years and standard deviation (SD) of 12.3 years. The highest score was observed in mental health domain (60.09±18.35), followed by physical functioning (45.21±9.20), energy and vitality (44.06±9.60) and bodily pain (43.06±17.76) whereas the lowest were role limitation due to physical problems (26.19±9.32) and role limitation due to mental health (25.87±9.13). The overall QoL score ranged between 23.75-54.13 with a mean±SD of 39.42±5.41. Among studied sociodemographic factors, there was a negative significant correlation between patients` age and total QoL score (r=-0.152, p=0.020) while among diabetes-related factors, there was a negative significant correlation between patients` HbA1c% level and total QoL score (r=-0.457, p<0.001). Conclusions: Quality of life of type 2 diabetic patients was adversely impacted by some sociodemographic and diabetes-related factors. Therefore, social and psychological support of those patients should be a must.