Objective: Assessment of quality of life in children with heart disease and various factors affecting it. Method: This is a cross sectional observational study, all children with heart disease were enrolled and their demographic and clinical information was collected using pre designed and pre tested proforma. Quality of life of children was assessed by peds QOL 4 scale. The results were analyzed by SPSS software version 25. Results: There were 60 children out of which 28, 17 and 15 are in age group2-4,5-7 and 8-12 years respectively, 52 % were male and 48% were female. According to their residence 52% were urban and 48 % belong to rural area. It is found that children belonging to higher socioeconomic status groups experiencing better QOL (quality of life) in all domains (p value 0.015), children with cyanotic heart disease shows poor QOL as compared to acyanotic and rheumatic heart disease (p value 0.04). Children with surgical management showed better QOL as compared to children on medical management. No significant association was found between QOL age, sex, residence and maternal educational status Conclusion: In children with heart disease, quality of life is affected by type of heart disease, medical or surgical management, socioeconomic status. It was found that surgical management improves quality of life.