Background: Trauma can cause rhabdomyolysis through direct muscular injury due to crush or blunt injuries (e.g., road traffic accidents, falls, natural disasters, child abuse) as well as by electrical or thermal burns, Aim: Aims of the study was to assess the outcomes of severe polytrauma children suspected of having crush injuries attending to the emergency department of Suez Canal University Hospital; To assess the relevant risk factors; To assess our current management and effects on outcomes; and To assess the knowledge, practice and competence of the emergency doctors after application of a proposed guidelines. Patients and Methods: The study was an interventional prospective study. The study was conducted at Emergency department in Suez Canal University Hospital. Results: Hb <10 g/dl was the only risk factor that was statistically significantly related to MT. The AUROCs of Hb <10 g/dl and BIG score were fair while the AUROC of Hct <35% was good in predicting MT. Conclusion: Our results indicate that our management through application of proposed treatment guidelines can modify outcomes of polytraumatized children with musculoskeletal injuries and suspected of having crush injuries. Our statistical model includes several outcome predictors that can help to create criteria for assessment and management of suspected crush injuries in pediatric polytrauma patients.