Background: The alarming increase in type 2 diabetes mellitus (T2DM) in Saudi Arabia is aggravated by increasing obesity, sedentary lifestyle, and population aging. Over 19.4 million adults aged 20–79 years people globally are affected by Type 2 diabetes mellitus. The Kingdom of Saudi Arabia (KSA) has declared a new vision for 2030, which includes an aim to improve the quality of healthcare in the Kingdom while maintaining the efficacy of spending. The health impact profile Type 2 diabetes mellitus((T2DM) is a quality of life instrument that helps evaluate health status. Type 2 diabetes mellitus (T2DM) and its treatment impact patients’ physical health as well as emotional and social wellbeing. This study aimed: To assessment of the Health-related quality of life among patients with type 2 diabetes mellitus in, Makkah City, Saudi Arabia at a tertiary care hospital, was conducted on August 1, 2021. Method: A cross-sectional study was conducted among patients with type 2 diabetes who attended a tertiary care hospital in Makkah at Saudi Arabia in 2021. Participants were interviewed and their medical records were reviewed. Our total participants were (300). Results: most of the participants (44.0%) were in the age group 25-50 years follow by the (38.0%) were in the age >50 years, the majority of them were males (66.0%) while female(34.0%), also regarding level of education the majority of participant are Intermediate level were(42.0%), while Secondary were(29.0%(. Regarding the economic level the majority of participant high economic levels were (38.0%). While Smoked most of participants (52.0%) not smoking while yes smoked were (48.0%), distribution the of the patient's with satisfaction and heave a significant relation between the satisfaction and frequency while P-value <0.001 and X2 170.820, participant toward Satisfaction study results show the majority of participant had Satisfied were(74.0%) while Non satisfied were(26.0%) but total (100%) Conclusion: Overall, patients with T2DM had lower HRQoL than the general population, which was attributed to being older age, longer duration of diabetes, insulin use, obesity, inadequate glycemic control, and diabetes-related complications. The patient’s good knowledge of T2DM disease was not reflected in the patient’s attitude and practice towards T2DM. Therefore, the local health authorities need to implement health education and awareness of clinical.