Background: One of the most prevalent neglected tropical illnesses is schistosomiasis, which is particularly prevalent in impoverished nations in Africa South America, and Asia. Schistosomiasis cases in Saudi Arabia are among the highest in the world. In Saudi Arabia, schistosomiasis is common, especially in rural areas. This rural Saudi Arabian community-based organization; According to the World Health Organization, controlling schistosomiasis morbidity through integration into the current health care delivery systems is thought to be a potentially sustainable and cost-effective strategy. Endemic community members were aware of the disease's widened scope and connected some reproductive health-related signs and symptoms to S. haematobium infection. A number of studies were carried out in Saudi Arabia to evaluate clinical features and variables related to the incidence of communicable illnesses, which in turn underlined the need for greater public knowledge of disease control in the local population. Aim of the study: To evaluate the level of knowledge among healthcare professionals working in Makkah City's primary care in Saudi Arabia in 2022 on the causes, signs, and symptoms of schistosomiasis. Methods: Across sectional descriptive study was conducted about the Knowledge of schistosomiasis signs and symptoms among health care workers at the primary healthcare in Makkah City from September to November 2022. Our total number of participants was (200). Results: Indicated that most of the participants approximately (48.0%) were aged from <30 years, sex, and educational level; this table reveals that approximately of participant (27.0%) were in university; regarding the Toilet facility, most of the participants Pit (ground dug) were(77.0%) while Pour flush system was (23.0%), regarding the drinking water the most of participants unsafe were (56.0%), Sources of knowledge about schistosomiasis signs and symptoms the majority of participant Health clinic/hospitals were (40%). Conclusion: Schistosomiasis is still prevalent among the rural population in Saudi Arabia and participants’ knowledge about the disease was poor. based health education regarding schistosomiasis is imperative among these communities to significantly reduce the transmission and morbidity of schistosomiasis community mobilization and health education regarding the cause, transmission and prevention of schistosomiasis and education about good personal and sanitary hygiene practices.