Background: people and Children's infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been increasing dramatically. COVID-19 precaution measures are essential for highly susceptible groups. However, it was not known previously to what extent chronic disease patients were perceived to know about the efficacy of prevention measures. Novel coronavirus-2019 is a highly infectious disease that caused a global pandemic around the world. Saudi Arabia is one of the countries that initiated early vaccination programs despite the global challenges concerning the availability of COVID-19 vaccines. Massive vaccination campaigns have been undertaken in the country; however, negative perception and hesitancy toward vaccines may exist which could reduce public response to vaccination especially the children. Further, studies evaluating the current perception and attitude toward COVID-19 vaccines are scarce especially the children. People’s and Children's perceptions of pandemic-associated risk are key factors contributing to increased public participation in disease preventive measures. Aim of the study: To assessment of the knowledge of The Risk Perceptions Attitude About The Vaccination Against Covid-19and communication practices of vaccinate about Covid-19 among Children's Saudi in Makkah Al-Mokarramah , Saudi Arabia2022. Method: Cross sectional study, was utilized in the present study among secondary school children and conducted from January to April 2022. conducted among Saudi Arabia primary health care center and secondary school children in Makkah Al-Mukarramah 2022. Our total participants were(200). Results: Regarding Attitude of the participant toward symptoms of the Vaccinate against COVID-19 Show that is a significant correlation in attitude were p-value =0.001 and X2 63.64, the majority of participant in weak attitude were(57.64%) followed by average were(32.0%), regarding the practices Show that is a significant correlation in practices were p-value =0.001 and X2 85.72. Conclusion: During the COVID-19 pandemic, communications designed to promote the adoption of preventive behaviors should focus on increasing the perception of seriousness. Health education programs that are tailored to various socio demographic categories, to improve public awareness, perceptions, and attitudes, are vital for increasing the adoption of outbreak preventive measures.