Globally many countries and families are facing large scale of health-related problems which needed to addressed according to needs and issues of the person’s condition. Cancer is one of non-communicable disease with causing more problems for many families. The cancer treatment is becoming nowadays very cost effective due to different modalities for treating the particular type of cancer. Aim and objective: The aim of study to evaluate the life and factors influencing their live hood. The objective is to assess the level of quality of life among patients undergoing chemotherapy and to associate the quality of life among patients undergoing chemotherapy with selected demographic variables at selected hospitals, Puducherry. Methodology: A quantitative approach with survey design was conducted among patients receiving chemotherapy in selected cancer hospitals, Puducherry. Totally 60 samples were recruited by using purposive technique of sampling. The data collection was carried out with modified quality of life among patients among chemotherapy using structured questionnaire 5-point rating scale with 25 items. Results: The study results revelated that, majority 59 (98.33%) of patients had unsatisfactory and only 1 (1.67%) had uncertain quality of life. Further, the data was analyzed by using Chi-square test to associate the quality of life with selected demographic variables such as the participant undergoing number of chemotherapy cycles (Chi-square =60.0, df=3, p=0.0001) is statistically significant at p<0.001. Finally, the research findings indicate the awareness should be created among patients to get and utilize the resources available in governmental and non-governmental sector as a free of cost.