Gastrointestinal tract (GIT) is considered one of the key aspects for the overall health of the human beings. Along with its primary function which is the chemical and physical digestion and absorption of nutrients, GIT has its own vital defensive immunological role through the mucosal immune system. The protection and management of infectious and non infectious diseases affecting GIT is required, especially those affecting the GI mucosa in order to preserve its normal function. One of the common GI illnesses is the peptic ulcer disease (PUD), sometimes called stomach ulcer or gastric ulcer. The research aimed of the study is to assess the quality of life in patient with peptic ulcer before and after the treatment using psychological general wellbeing index.