Colorectal adenocarcinomas constitute approximately 90% of the malignant large bowel tumours. The absence of symptoms is a common characteristic of early-stage colorectal cancer; thus, early detection through screening programmes is critical. The objective of this investigation is to study the effects of selected plant extracts for colorectal adenocarcinoma cell line by MTT assay. Three plants have been selected for the MTT assay are Vanda tessellata, Ipomoea aquatica, Semen armeniacae. In methodology Vanda tessellata and Ipomoea aquatica, “leaves were extracted with PE followed by DCM and then MeOH. Semen armeniacae was extracted with PE followed by EA and then MeOH”. Colorectal adenocarcinoma cell line used in MTT assay viz Colo205 were procured from “National Centre for Cell sciences, Pune, India”. Results depicted that Vanda tessellata extracts were 100% proliferative against Colo205. Phytomedicines accomplish this by means of the additive or synergistic effects of multiple chemical compounds that target a single or multiple sites on carcinoma that are linked to a physiological process. The inhibition of various signal transduction pathways implicated in tumour development has been observed in phytochemicals.