Introduction and Aim: Endothelin-1 (ET-1) and Vascular Endothelial Growth Factor-A (VEGF-A) have been recognized as markers of endothelial dysfunction in diabetes mellitus. VEGF-A and ET-1 are vasoactive peptides that have a nexus with vascular manifestations including optic neuropathies and disturbances in retinal circulation. This study compared vascular dysregulatedmetrics,VEGF-A and ET-1 with insulin resistance and sensitivity, in the light of riskfactors for diabetic nephropathy in a graded manner, based on albuminuria. Subjects and Methods: A total of 90 type 2 diabetics in the age group 35 -50 years were enrolled as three groups, comprising 30 each, based on albuminuria. 30 healthy age and gender matched subjects constituted the control group.VEGF-A, ET-1 and Insulin were quantitated by ELISA. Microalbumin was estimated by turbilatex method. Routine biochemistry analyses wascarried out on fully automated analyzer. Stringent quality control was promulgated . The study was begun following approval accorded by the competent authority. Results:The dysregulated metricspositivelycorrelated with HOMA-IR (Insulin resistance)andalbumin-creatinine ratio.; VEGF-A, ET-1 negatively correlatedwith HOMA-β (Beta cell mass), QUICKI (Insulin sensitivity)and eGFR.Thus, VEGF-A and ET-1 might find clinical utility as indicators of imminent vascular problems. Conclusion:VEGF-A and ET-1, with reference to theindicators of insulin resistance, insulin sensitivity and Beta cell mass would acquire significance, in the light of albuminuria, as biomarkers in angiopathy related to diabetic nephropathy