Periodontitis is a chronic, multifactorial, polymicrobial disease causing inflammation in the supporting structures of the teeth. Depression is associated with a chronic, low-grade inflammatory response, activation of cell-mediated immunity, and compensatory anti-inflammatory reflex system, as well as an augmentation of oxidative and nitrosative stress, which contribute to neuroprogression in the disorder. The inflamed periodontal pocket can, be a significant source of inflammatory and pathogen-derived mediators,which can cause neuro inflammation leading to depression.The aim of the study is to know if there is an association between Periodontal disease and depression. Methods: The study group consisted of 500 patients visiting the general outpatient department (OPD) of Malabar dental college. Periodontal parameters like Plaque index, Gingival index, maximum probing depth, and maximum clinical attachment loss were measured. Based on the clinical findings they were divided into three groups, namely healthy, gingivitis, and periodontitis group. To those patients becks depression inventory was given. To correlate the association between different forms of periodontal disease and depression was evaluated. Results & Discussion: All the participants completed the study. The results showed that depressive scores are increased in periodontitis group than in the healthy and gingivitis group (p value <0.001)and was found to be highly statistically significant