Monkeypox is the latest disease to hit the headlines in a troubling trend for emerging diseases. India is 10th country in Asia and 1st country in South Asia to report monkey pox case. Till now in India, there are 23 human reported cases of monkey pox. A zoonotic orthopoxvirus, monkey pox or MPXV can cause disease in humans same as smallpox, but its mortality is low. Although, by eradicating smallpox and lack of its vaccination efforts gave monkey pox to gain relevance clinically. The objective of this review is prevent human to human transmission of monkeypox, to prevent vulnerable humans which are at high risk and to limit the zoonotic transmission of monkeypox infection.