Background: Hypertensive disorders during pregnancy increase maternal and infant risk. The greatest impact is associated with the being pregnant-specific syndrome, preeclampsia, a always clinically worsening situation. PE is a complication of being pregnant, constituting a primary cause of maternal and foetal morbidity, and mortality Hyperuricemia and elevated CRP level, in pre-eclamptic patients need to be confirmed, in a designed method, wherein uric acid and CRP level are measured before the development of preeclampsia, or early in pregnancy, in order to identify and monitor the patients, “at risk of preeclampsia”, and thus provide the best prenatal take care of these women and their babies. Methods: The study become performed in Obstetrics and Gynecology department, PBM hospital, SPMC Medical College Bikaner, Rajasthan, India. The study duration was 12 months. It is a prospective type of study comprising of patients. Serum uric acid and C-reactive protein had been estimated along with different routine investigations for all patients attending. All the subjects have been divided into groups: (i) group-1 (study group): 60 diagnosed pre-eclamptic patients in 1/3 trimester of pregnancy (37-40 weeks) whose serum uric acid and CRP ranges were already raised during her antenatal visits in 2d trimester, (ii) group-2 (control group): 60 normal pregnant women of comparable gestational age Results: The mean values of serum uric acid and CRP ranges remain higher in study group than that of control group. This difference is statistically significant (p= 0.02). Conclusions: All the patients in study group whose measurement of uric acid and CRP levels were high, evolved pre-eclampsia. So, it can be fairly concluded, that the determined elevations in serum uric acid level or CRP level or both, preceded the development of pre-eclampsia.