With a lifetime prevalence of 15-20%, AD, is one of the most prevalent inflammatory skin disorder in developed nations. Now, it is mainly concerned for factors like epidermal barrier disruption, T cell subset activation, and skin microbiome dysbiosis. Its relationship pathology with asthma, allergic rhinitis, and food allergies is yet unknown. As of October 1, 2017, the Global Health Data Exchange reported that the non-fatal disease burden of skin diseases is the leading cause of AD. Previous studies have also showed linked between environmental, and genetic factors. Thus, disease needs further research in this area .