Background: For assessment of awareness in nurses about reporting of ADR, this study was conducted among the nursing staff of Rural Tertiary care teaching hospital in western Maharashtra. Methods: This is a cross-sectional observational study conducted for a period of 3 months. Pre-validated questionnaire consisting of 20 questions was distributed among the nursing staff to assess their awareness attitude, knowledge regarding reporting of ADR. Results: 96% agreed that reporting of ADR is necessary. 90% thought that Pharmacovigilance should be taught to them. 88% felt that ADR Monitoring Centre should be established in every hospital & 66% believed that only serious ADRs need to be reported. 68% have experienced ADR during their working hours in hospital. Only 46% have ever reported ADR. 30% have ever seen the ADR reporting form. 50% have been trained on reporting of ADR. None of them knew that SAE should be reported within 24 hrs.