Objectives: to investigate the role and knowledge of pharmacists toward medication errors (MEs) and patients’ safety in Saudi Arabia. Methods: We conducted a thorough search of PubMed, SCOPUS, Web of Science, and Science Direct to find pertinent literature. Rayyan QRCI was utilized during the entire process. Results: We included ten studies and all of them were cross-sectional studies. Studies reported that MEs are common among clinical pharmacists, including errors in prescriptions were observed in the inpatient pharmacy services of the teaching hospital, they also understood the significance of reporting MEs and how doing so could enhance the standard of healthcare delivery. Additionally, community pharmacists are not well-versed in informing pregnant patients about the safety of prescription drugs. The prevalence of drug-related problems appears to be reduced by pharmacist interventions, highlighting the significance of an ideal pharmaceutical care plan for clinical care settings. Conclusion: The majority of MEs documented in the included publications included prescribing, which includes choosing improper drugs and doing so at the incorrect dosage. Reducing medication mistakes in children is mostly dependent on pharmacist interventions. The implementation of a ward-based pharmacist or a pharmacist-led medication safety program is one of these strategies, along with instructional sessions and the review and validation of drug orders.