Introduction: Electronic nicotine delivery systems (ENDS), known as e-cigarettes or electronic cigarettes, are battery-powered devices that produce nicotine without physically burning tobacco. This study assesses the awareness, perceptions, and use of electronic cigarettes among health care workers in Riyadh, Saudi Arabia. Findings will help in policy formulation on how to curb this issue, which causes health problems such as cancer. I am targeting health care workers because they are the front line in ensuring health for the Kingdom of Saudi Arabia. Methods: We will use a descriptive cross-sectional study to measure perception and awareness of e-cigarettes, identify the various factors associated with the initiation and use of e-cigarettes, and explore the reasons to use e-cigarettes among health care workers in Riyadh. I will conduct a pilot survey among a smaller sample of the population (n = 30) to explore the instrument's reliability and validity to produce accurate results. The pilot survey findings will be used to adjust the tool, and then a more extensive assessment will be conducted. The questionnaire will be self-administered. Results: The expected results will detail the current use of e-cigarettes, those trying e-cigarettes, intention to use e-cigarettes, and reasons to use as the dependent variables. Age, gender, working, and peers smoking, seeing e-cigarette advertisements, and receiving information about e-cigarettes through social media, which are the independent variables, will be analyzed in detail. Conclusion: Data will describe baseline awareness and usage of e-cigarettes to help public health authorities identify those groups more at risk of becoming established nicotine users. Findings can facilitate the development of public health strategies and the adoption of various policies to protect health care workers from adverse effects related to e-cigarettes smoking in Riyadh.