Infected wounds are manifested as a complication of trauma or due to various pathological conditions and are difficult to manage because of their non-healing nature. In Ayurveda, infected wounds can be compared with Dushta vrana. Besides other modalities of treatment; dhoopana karma has been emphasized in the management of such manifestations. Here is the case report of a patient with such complaints. A male patient of 59 years of age visited OPD of Shalya tantra with complaints of severe pain, swelling with non-healing ulceration over the dorsum of left foot with history of prolonged standing for the past 25 years. Local examination revealed an ulcer covered with some necrotic tissue with progressive inflammatory changes. Based upon the history and clinical findings; the case was diagnosed as Sirajanya Dushta vrana, as it was resulted from venous stasis. Sthanika dhoopana was done using gana dhoopa by following classical guidelines of Ayurveda. Simultaneously, cleaning of wound with Panchavalkala Kashaya and dressing with Jatyadi Taila were done for 20 consecutive days. Changes in size, shape, floor, and margin of the ulcer were recorded at regular interval. Pain and discharge were completely subsided after 15 consecutive days of dhoopana. Significant healing in wound observed after 20 days without any adverse effects. Once proved, these sthanika karma will definitely help wide acceptance of Ayurveda as a scientific health care system particularly in those regions of world where still it is strongly believed that Ayurveda is just a traditional method of health care with no or minimal understanding on scientific parameters