Biologically active secondary metabolites are produced by bacteria in remarkable amounts. These organisms have enormous biotechnological value due to their potential to synthesise the bioactive molecules. Microbes synthesise secondary metabolites in reaction to nutrition, growth rate, feedback control, enzyme inactivation and enzyme stimulation. With the aid of biotechnology, microbes are explored to produce desired biomolecules like enzymes, proteins, and other compounds with therapeutic applications. Ever since the discovery of penicillin, microbes from various habitats are being extensively analysed for their metabolites with medicinal properties. The emergence of drug resistance and deadly side effects associated with synthesised drugs, has forced the scientific community to dig deep into natural resources to combat the drug resistance and cater to the other deadly diseases. Since the last few decades, scientists and pharmaceutical industries are focused more on natural compounds with medicinal applications. In the current review article, we try to summarize the bacterial metabolites which have been identified as potential therapeutic agents.