Benzothiazole (1, 3-benzothiazole), a weak base is a crucial pharmacophore in heterocyclic compounds that displays a variety of biological properties due to its potent and significant pharmacological activities. The unique methylene centre at the C2 position present in the thiazole ring makes benzothiazole the most common and integral structure of many natural and synthetically synthesized molecules. Benzothiazole derivatives show a variety of activities, with less toxic effects, and their derivatives demonstrate proven enhanced activities.