Nature is one of the maximum critical resources of pharmacologically energetic compounds in the look for capsules against existence threatening diseases. The methylphenylthiazolylnaphthylmethanone were synthesized and characterized by different physicochemical techniques such as IR, 1H NMR, 13C NMR and Mass spectra. Marine organisms also have the potential to turn into destiny tablets towards critical illnesses, such as most cancers, a variety of bacterial and viral illnesses, malaria and inflammations. In addition, the Lipinski rule of five, molecular docking was used to calculate binding affinities and predict binding locations for the various receptors