Antiepileptic medication use is associated with an increased risk of bone metabolism issues, decreased bone mineral density, and two to three times the risk of fractures in children and adolescents compared to healthy controls. We combed through the research on vitamin D treatment in children taking anti-epileptic medications and bone mineral density in children diagnosed with epilepsy. Research on bone mineral density markers in epileptic children has often shown no statistically significant change. Some studies have used too small of a sample size, while others have failed to account for potential confounding variables like obesity, comorbidities, poor diet, or lack of movement. Vitamin D therapy studies in children with epilepsy have been underwhelming and have failed to account for potential confounding variables due to a lack of stratification. In order to better understand the effects of polytherapy, decreased mobility, and symptomatic generalised epilepsy on fractures and other clinically important outcomes, larger studies are required. Vitamin D therapy may help children with epilepsy whose bones are at risk for poor health, however there is currently no solid data to support this claim. It is crucial for neurologists to prescribe low-dose vitamin D supplementation and monitor compliance in children with epilepsy, since this is now recommended for healthy children and there is biological evidence to suggest that children with epilepsy may be more likely to experience clinically significant deficiencies. Due to its effects on blood calcium levels, dopamine generation, and regulation of many brain functions, exercise is considered a safe, non-pharmacological method of treating the brain. The stimulation of antioxidant and anti-inflammatory pathways further enhances its neuroprotective activity. Multiple studies have shown that many other factors contribute to epileptogenesis. Epigenetic mechanisms impact the pattern of transcriptomics, proteomics, metabolomics, and exposomics by modifying chromatin structure through processes such as DNA methylation, acetylation, deacetylation, ubiquitination, and histone phosphorylation. Epileptogenesis is closely associated with these processes.