The definition and classification of Chronic kidney disease (CKD) have evolved over time, but current international guidelines define CKD as decreased kidney function shown by Glomerular filtration rate (GFR) of less than 60 mL/min per 1.73 m2, or markers of kidney damage, or both, of at least 3 months duration, regardless of underlying cause. A prolonged decline in renal function and structural damage to the kidneys are prerequisites for the diagnosis of CKD. CKD is caused by a variety of diverse disease processes that, over the course of months or years, permanently impair the kidney's structure and function. Peripheral neuropathy caused by CKD is triggered by a number of factors. Significant axonal depolarization has been observed in CKD in the early stages of neuropathy. The acoustic and olfactory nerves are particularly vulnerable to the harmful consequences of uremia. In approximately 40% of those with CKD who participated in a brain stem auditory evoked potential (BAEP) investigation, the I-III interpeak intervals were prolonged, indicating the presence of auditory neuropathy. Following the start of hemodialysis, BAEP abnormalities improved or normalised in some individuals. Peritoneal dialysis does not help individuals with chronic kidney disease's hearing loss, according to prior studies. Patients with uremia can develop a classic myopathy, which is characterized by proximal muscular weakness, muscle atrophy, and typical electromyographic characteristics of myopathy