Background: Fluid therapy is a cornerstone in the perioperative care of patients undergoing hepatectomy with a major controversy regarding which, when and how much fluid should be given peri-operatively. Fluid management strategies have undergone several shifts over the past 50 years. The choice of fluid became the subject of intense debate and continued until today, using colloid versus crystalloid and applying fluid restriction strategy or less restrictive strategy. Recently, there is interest in the concept of achieving a supernormal oxygen delivery and avoiding anesthesia-related harm after surgery such as prescribing individualized goal-directed fluid therapy (GDFT).