Background: Endoscopic sinus surgery (ESS) is currently accepted as the treatment of choice for chronic sinusitis resistant to medical treatment. The concept behind sinus surgery stems from Messerklinger's studies on mucociliary clearance and its role in the pathogenesis of sinusitis. Use of Platelet-rich plasma (PRP) is of interest particularly among orthopedicians and sports medicine experts due to its regenerative and tissue healing effects. New applications of platelet-rich plasma are also being investigated. This material is particularly interesting to the ENT surgeon because of its healing properties and as a potential packing or grafting material. The contribution of platelet-rich plasma to tympanic membrane healing following bilateral tympanic membrane perforation were assessed showing promising results. Also, method for the autologous transplantation of fat and platelet-rich plasma was investigated to treat atrophic rhinitis, All patients described symptom improvement, with the disappearance of nasal crusting.