Background: Under normal physiological circumstances, the BP reading is often same for both the arms. However, a BP difference between both arms is frequently encountered in various general populations. Inter-arm blood pressure difference (IAD), also known as interarm systolic blood pressure difference (IASBPD), refers to the variation in systolic blood pressure measurements between the left and right arms. It is normal to have an IAD of <5 mmHg. An IAD is defined as a variance in systolic BP of >10 mmHg. It has emerged as a clinically significant parameter that can provide valuable insights into cardiovascular health and risk assessment. The measurement of blood pressure in both arms has gained attention as a simple, non-invasive method to identify potential underlying vascular abnormalities and to evaluate the risk of cardiovascular diseases. Understanding the clinical significance of IAD has prompted researchers and healthcare professionals to explore its potential as a risk marker and prognostic indicator. The evaluation of IAD can provide valuable information regarding underlying vascular pathology and may contribute to risk stratification and treatment decision-making. Additionally, IAD assessment can be easily incorporated into routine blood pressure measurements, making it a practical and cost-effective tool in clinical practice. Coronary artery disease (CAD) is a cardiovascular disease which has been found to be the leading cause of death in both developed and developing countries. CAD is an atherosclerotic disease which is inflammatory in nature, manifested by stable angina, unstable angina, myocardial infarction (MI), or sudden cardiac death. Risk factors for CAD include high blood pressure, high cholesterol, smoking, diabetes, and a family history of heart disease. CAD is often diagnosed through a combination of tests, including a physical exam, blood tests, and imaging studies such as an electrocardiogram (ECG), echocardiography and a coronary angiogram. Treatment options for CAD include lifestyle changes, medications, and procedures such as angioplasty or coronary artery bypass surgery.