Onychomycosis is an infection of the nail unit caused by fungi (dermatophytes, non-dermatophyte molds, and yeasts), presenting with discoloration of the nail, onycholysis, and nail plate thickening. Any component of the nail unit, including the nail plate, nail matrix, and nail bed can be affected. The term “onychomycosis” is derived from the Greek words “onyx” meaning nail and “mykes” meaning fungus. Onychomycosis is the most common disorder affecting the nail unit and accounts for at least 50% of all nail diseases. The advancement of laser/photodynamic therapies and their application in onychomycosis has emerged as a new therapeutic paradigm as they successfully negate systemic adverse effects, drug interactions, and frequent application. Their ultimate success depends on their retention, payload, and final disposition at the targeted site of action. It appears that laser/photodynamic therapies could address the problems associated with treating onychomycosis, and offer a novel drug delivery platform for its successful treatment. Promising laser-based treatments for onychomycosis have been reported in recent years. Such therapies include Nd:YAG laser treatment and diode lasers with wavelengths of 870/930 nm