The skin represents a complex ecosystem. A large and diverse community of microorganisms is present on the body. Depending on the ecological niches, the bacterial distribution can vary .Thus, in a lipidic area, Actinobacteria are more represented, and Cutibacterium acnes can represent until 70% .This anaerobic-aerotolerant Gram-positive bacteria is a skin commensal, and its ecological niche is represented by the sebaceous follicles.C. acnes is able to produce numerous virulence factors. Thus, it produces short-chain fatty acids (leading to a local infammation) which contribute to antibiotic resistance.The mechanisms of antimicrobial resistance of c. acnes in acne mainly involve bioflm formation and genetic mutations in ribosomal RNA (rRNA), leading to higher virulence and transmission of resistant bacterial strains. New treatment approaches targeting c. acnes may include bacteriophages, natural synthetic antimicrobial peptides, probiotics, anti-bioflm agents