Background: Many unicellular and multicellular microbial populations, including bacteria, viruses, fungus, and parasites, are hosts for all humans and other animals. Both the environment and the human body are home to a wide variety of microbes. The term "microbiota" was developed in 2020 by a group of international specialists composed of more than 100 members. They came to the conclusion that the microbiota is made up of prokaryotes and eukaryotes and that is active in a variety of microbial structures, metabolites, and moveable genetic elements. Numerous distinct (micro-)niches for microbial communities are provided by the topography of the upper respiratory tract and its various epithelial linings and circumstances. The microbial community structures in other locations in the nasal cavity and down the nasopharynx are distinct, especially in adults. While the anterior naris (the passage between the skin and the nasal cavity) harbours commensals and opportunistic pathogens such as Staphylococcus aureus, S.epidermidis, Propionibacterium (now: Cutibacterium) acnes, Dolosigranulumpigrum, Finegoldiamagna, Corynebacterium spp., Moraxella spp., Peptoniphilus spp.,and Anaerococcus spp., Even though the URT microbiome is mostly individual, alterations in inter-individual bacterial community profiles throughout various ages and seasons (winter vs. summer) can nevertheless be seen.