Bullying is defined as a form of aggressive behavior that occurs in an intentional and repeated manner causing another child to feel hurt. Bullying can take multiple forms, including spreading rumors, threatening, physical or verbal assault, engaging in insidious practices such as excluding a child from a group to hurt him/her, or any other gestures or actions that occur in a less visible manner. Bullying prevention program in the schools with an aim to improve the overall health of the adolescents contribute in achieving the United Nation’s Sustainable Development Goals, three and four, of ensuring good health and well-being, and providing quality education, respectively. Aim: To identify bullying prevention methods commonly used in schools, to assess their effectiveness based on the evidence reported in interventions and reviews to highlight the most appropriate techniques to design an optimal strategy to improve adherence to data reporting, and provide recommendations for future interventions and research, Methods: A study of MEDLINE was made, all scientific literature published from May2020until April 2023 in PubMed & Web of Science [Science Citation Index Expanded), Social Sciences Citation Index, & Emerging Sources Citation Index] were included Summary: Bullying is the most prevalent potentially modifiable risk factors for mental health disorders, thus rendering it a major public health concern and a major target for universal prevention given the high prevalence rates, association with increased lifetime prevalence of mental health disorders and converging evidence supporting the feasibility and cost-effectiveness of anti-bullying interventions