Burn injuries are a significant global health concern, necessitating comprehensive and multidisciplinary care approaches for optimal patient outcomes. This review delves into key aspects of burn care management, including epidemiology, pathophysiology, initial assessment, acute care interventions, rehabilitation, complications, emerging technologies, best practices, future directions, and challenges. The epidemiology highlights the varied incidence and prevalence of burn injuries globally, emphasizing age, gender distribution, etiology, and severity classification systems. Pathophysiological mechanisms of burn injuries, encompassing thermal, chemical, electrical, and radiation burns, as well as local and systemic responses, are discussed to inform treatment strategies. Initial assessment and stabilization protocols are crucial in managing burn injuries effectively. Prehospital care, primary surveys using the ABCDE approach, fluid resuscitation strategies, and pain management techniques are pivotal components of acute care. Subsequent sections address acute burn care, rehabilitation, and long-term management, focusing on wound assessment, debridement, dressing techniques, surgical interventions, infection control, scar management, psychosocial support, and nutritional considerations. Complications associated with burn injuries, including respiratory, sepsis, metabolic, and psychological sequelae, are examined to guide comprehensive patient care. Emerging technologies such as advanced wound healing products, telemedicine, regenerative medicine approaches, and artificial intelligence applications offer promising avenues for enhancing burn care outcomes. Best practices and guidelines based on international standards, evidence-based protocols, and quality improvement initiatives underscore the importance of standardized care delivery. The review concludes by exploring future directions in burn care research, addressing healthcare disparities, sustainability considerations, and advocating for collaborative efforts to advance burn care knowledge and improve patient-centered care delivery.