Background: Burnout is characterized by three dimensions: feelings of energy depletion or exhaustion; increased mental distance from one’s job, or feelings of negativism or cynicism related to one's job; and reduced professional efficacy”. The Aim of this study was assess burnout and associated factors among nurses at Al-Ahrar Zagazige Teaching Hospital. Subjects and Method: Cross-sectional design was used in this study. Setting: The study was conducted at Al-Ahrar Zagzag Teaching Hospital. Subjects: A convenient sample of 120 nurses working in the previous mentioned setting. Tools: data were collected using tow tools, Tool (I): Socio-demographic data and work related factors. Tool (II): Maslach Burnout questionnaire. Results: the result of study indicated that Majority of studied nurses were working 36 hours/ week and staff nurses. More than three fifths of nurses were married, female, working at intensive care units and emergency department. Majority of studied nurses had low scores of depersonalization, personal accomplishment, Emotional exhaustion and total burnout. Conclusion: Majority of studied nurses had low level of depersonalization, personal accomplishment, Emotional exhaustion, and total level of burnout. No statistical significant relationship between burn out score and demographic and work related factors of studied nurses. Recommendations: Periodical assessment of nurses’ burnout should be done regularly for early detection and develop training programs to improve their coping abilities and decrease burnout.