Approximately 20% of patients who undergo major surgeries are affected by serious complications. Whereas some complications resolve quickly with negligible consequences, more serious complications may necessitate invasive re-interventions and are associated with lasting morbidity and even mortality. Clinical diagnosis of infections, inflammatory diseases, and response monitoring can be done by C- reactive protein (CRP) testing which is an acute phase protein produced by liver. CRP measurement in the perioperative period was studied, and patterns of change were analyzed, for elective general surgical patients . Study aimed to test the efficacy of C-reactive protein as a predictor for surgical stress and diagnostic accuracy to detect early postoperative complications due to infection. Objective of this study was to estimate perioperative serum C-reactive protein level in patients undergoing elective surgeries to find out the relation between serum C-reactive protein values and severity of surgical stress and also to find out the diagnostic accuracy of C-reactive protein to detect early postoperative complications due to infection.