Introduction: The COVID-19 infection is associated with an aggressive inflammatory response known as “cytokine storm.” This overwhelming inflammation, may lead to many adverse outcomes or even death. The impact of the pandemic is not only limited to case numbers and mortality rates, but also deeply extends into the mental health of the global population. Depression appears to be a common complication in patients during and post–COVID-19 infection. In recent, many studies have revealed role of inflammation in pathophysiology of depression.