Justica Adhatoda also known as Malabar nut, has its several applications in the medicinal utility. It is found in most of the Asian countries. The leaves and roots of the adhatoda are particularly used for the respiratory tract aliments. The alkaloid vasicine has been employed as an oxytocic and abortifient agent over more than 20 years. The present study is designed to bring the ability of the constituents to tackle with the prevailing insulin resistance. The structures were found by literature review, and drawn by Marvin Sketch. They were docked using AutodockVina with the certain targets of inflammatory cytokines such as Tumour necrosis factor (TNF-α), Interleukin (IL-6), and also with the insulin receptor substrate IRS-1, protein kinase B (AKT),and mammalian target of rapamycin (mTOR). The constituents were found to bind with the targets by van der waals interaction with the docking score in the range of -3 to -8 kcal/mol. The toxicity levels were also analyzed. Our research leads us to believe that screened phytochemicals found in Justica adhatoda can be employed as therapeutic medication candidates to treat insulin resisance.