Acute pancreatitis (AP) is an unusual complication in the immediate post operative period following kidney transplantation surgery and has significant morbidity and mortality. Considering post-operative pain status, it is difficult to diagnose acute pancreatitis only on clinical background, warranting early suspicion and diagnosis. Tacrolimus, a calcineurin inhibitor, is a commonly used drug in kidney transplantation immunosuppression protocols. Although various adverse effects, including hepatotoxicity, nephrotoxicity, neurotoxicity, infection have been reported, there has been limited data with tacrolimus associated pancreatitis in kidney transplantation. Herein, we report the case of Tacrolimus induced AP in a living related kidney transplant recipient in the immediate post operative period.