Tumours in and around the mandible usually require surgical removal of the lesion and extensive resection of the bone. Smaller lesions removed without discontinuity of the bone are relatively simple to restore with prosthesis. Larger lesions that extend to the floor of the mouth may be more difficult to restore with prosthesis even though the continuity of the mandible is maintained. Acquired mandibular deviation following surgical resection of the mandible can affect the normal masticatory function, speech and esthetics. This clinical report describes the fabrication of a cast metal guiding flange prosthesis, which could be used as a suitable alternative to the conventional resin guiding flange prosthesis in correcting mandibular deviation.