Oxidative stress is a condition that occurs due to an imbalance between the production of free radicals and the antioxidant defense system in the body. One of the free radicals that is harmful to the body is exposure to paraquat which enters the body in several ways, namely ingestion, through broken skin, and through inhalation.Paraquat poisoning causes various diseases, damage to cells, tissues, liver, kidneys, heart and degenerative conditions such as aging, arthritis, cancer and others.The large amount of free radicals in the body cannot be neutralized by endogenous antioxidants, so the body requires a supply of exogenous antioxidants. The chayote has Secondary metabolic content such as alkaloids, saponins, cardenolin/bufadienol, folifenol, flavonoids, vitamin C and minerals that are beneficial to the body. As a free radical neutralizer, the role of exogenous antioxidants such as chayote in health is very large. This study attempts to relate the content contained in chayote as an exogenous antioxidant to paraquat exposure by PESearch studies through the PubMed, Scopus and ScienceDirect databases using keywords based on the PICO formulation (Population, Intervention, Comparison, Outcome).After going through the PRISMA flow selection stage, 15 of the most suitable literature were obtained. Studies were selected with multiple inclusion and exclusion criteria, screened full articles and evaluated studies using an evidence-based critical appraisal checklist.