Relationship of atherosclerosis and coronary course sickness notable principal pathophysiologic reason for Ischemic Heart Illnesses and Myocardial Dead tissue and because of significant gamble factors, for example, high plasma level of low thickness lipoprotein, low plasma level of high thickness lipoprotein, cigarette smoking, hypertension and diabetes mellitus, contamination with few irresistible specialists, for example, Mycoplasma pneumoniae that could related with atherosclerosis consider as another gamble factor for ischemic heart infections. Point of this study is to research the job of this creature and its relationship to the gamble of openness to Mycoplasma pneumonia contamination for ischemic heart illnesses in Indian populace. This was a case-control concentrate on in which 96 patients considered and they were in two gatherings: The first group, also known as the case group, consisted of 48 units of patients who had been admitted to the hospital with a diagnosis of ischemic heart disease, such as unstable angina and myocardial infarction (STEMI, NSTEMI). The second group, also known as the control group, consisted of 48 units of healthy patients who did not have a history of ischemic heart disease that could be changed, and their age index was comparable to that of the first group. The ELISA method was used to test for IgG antibodies against Mycoplasma pneumoniae in both groups. 15 cases out of 48 in the case group and 3 out of 48 in the control group tested positive for antimycoplasma antibody in both groups. There was critical measurement distinction in antimycoplasma immune response level. The estimated relative risk of mycoplasma infection for ischemic heart disease is five in each group (p = 0.004). It appears to be that Mycoplasm pneumoniae contamination is a gamble factor for Ischemic Coronary illness, in Indian populace. This is the primary report investigation of such an illness in India. To better understand the interactions between the risk of Mycoplasma pneumoniae and Chlamydia pneumoniae infections and conventional risk factors for ischemic heart disease in this country, additional research is necessary