Chrozophora plicata, a traditional medicinal plant, is known for its potential therapeutic properties and has been used in various herbal remedies. This research aimed to conduct a pharmacognostic and phytochemical evaluation of the leaves of Chrozophora plicata to provide valuable insights into its medicinal potential and chemical composition. The physicochemical analysis of the powdered leaves revealed favorable results, indicating the quality and purity of the plant material for medicinal use. The presence of glycosides, tannins, flavonoids, resins, steroids, proteins, fats & oil, and saponins in the phytochemical investigation suggests its potential antioxidant, antimicrobial, anti-inflammatory, expectorant, and anti-inflammatory properties, validating its traditional use. However, alkaloids, phenol, diterpens, and amino acids were absent, further clarifying the chemical profile of the plant extract. These findings support the traditional use of Chrozophora plicata and provide scientific evidence for its potential therapeutic benefits. Nevertheless, further research is warranted to explore its pharmacological activities, efficacy, and safety in various disease models. Standardization of the extract's active compounds and optimization of its dosage forms will be crucial to ensure its safe and effective use in modern healthcare practices. In conclusion, the pharmacognostic and phytochemical evaluation of Chrozophora plicata leaves offers a comprehensive understanding of its chemical composition and medicinal properties. Embracing this traditional herbal remedy, along with appropriate scientific validation, may open new avenues for the treatment and management of various ailments, leading to better health outcomes for individuals and communities