This article presents the most significant risk factors that together contribute to the combined development of ischemic stroke and myocardial infarction: ventricular extrasystole, chronic heart failure, postinfarction cardiosclerosis, atrial fibrillation; the prognostic significance of the thickening of the intima-media complex and the tortuosity of the carotid and vertebral arteries has been proven. The predominance of cardio embolic stroke was established in combination with myocardial infarction, which proceeds with maximum severity, ending in death in more than 3/4 of patients. The high frequency and severity of ischemic stroke in combination with myocardial infarction in women has been proven. The leading risk factors for the combination of ischemic stroke and myocardial infarction are female sex, old age, ventricular extrasystole, chronic heart failure, postinfarction cardiosclerosis, tortuosity of the brachycephalic arteries, thickening of the complex intima-media, duration of hypertension over 7 years in men and 17 years in women, atrial fibrillation.