This study's goal was to look into the clinical trends and patch test results of hand eczema among hospital staff at a tertiary care facility in South India. Methods: The study involved 200 hospital personnel who had hand eczema. Results from patch tests, clinical patterns, and demographic information were all documented. To ascertain the prevalence of clinical patterns and particular allergens related to hand eczema, data were analysed. Results: The most frequent clinical pattern seen was irritant contact dermatitis (ICD), followed by allergic contact dermatitis (ACD). The main presenting feature was dry fissured hand eczema. Patch testing showed positive reactions in 47% of subjects; the main sensitizers were nickel sulphate, potassium dichromate, and scent mixture. Hand eczema was also strongly influenced by occupational allergens including formaldehyde and latex. Conclusion: The study's findings show that hospital staff members with hand eczema frequently develop allergic and irritating contact dermatitis. Patch testing allowed for the identification of the main sensitizers, which were nickel sulphate, potassium dichromate, and fragrance mixture. Hand eczema in this population was significantly influenced by occupational allergies. The prevalence of hand eczema among hospital staff must be decreased, and these findings highlight the need for preventive strategies and therapies that target occupational and non-occupational allergens.