Pain is a multifaceted experience involving physiological, cognitive and emotional aspects. Neuropathic pain is very challenging to manage because of the heterogeneity of its aetiologies, symptoms and underlying mechanisms.The objective of this article was to merge current treatment guidelines and best practice recommendations for management of neuropathic pain into a comprehensive algorithm for physicians. The algorithm involves assessment, multidisciplinary conservative care, pharmacological management, interventional therapies, neurostimulation, low-dose opioid treatment, and targeted drug delivery therapy.