Children were thought to be spared from SARS Cov-2 initially but a month within this epidemic not only adults but also children were affected. Multisystem inflammatory syndrome (MIS) is a serious condition that occurs rarely but it affects children. The aim was to evaluate clinical profile and outcome of children with multisystem inflammation in children. Methods: An observational retrospective study with children aged 2 months to 12 years at Tertiary care centre, MGM Medical College and Hospital, Aurangabad for a duration of 2 months from September, 2020 to November, 2020. Inclusion and exclusion criteria were set and ethical clearance was obtained. Demographic, disease characteristics, blood investigations, chest Xray, COVID rapid antigen test and RT-PCR and inflammatory marker details were noted at the time of admission and discharge. All the data was entered in Microsoft excel and analysed using SPSS version 24. Results: The average age group of the patients was 7 years. Most of the patients were from low socioeconomic status. Patients with fever >7 days had increased heart rate and respiratory rate. Whereas, average saturation was 92% and average COVID antibodies (SARS-Cov-2 IgG) levels were 4.8. As per Kuppuswamy classification of socioeconomic status 8(80%) patients were from lower middle-class group. The average duration of hospital stay was 7.4 days and 2D ECHO changes were seen in 30% of patients who had large thrombus and dilated coronaries at the time of admission. Conclusion: All the patients were given steroids, anticoagulants and or antiplatelet medications. None of them received IV Immunoglobulin. In our study 90% patients were cured with 10% mortality. Early supicion of immune mediated event following covid infection and early treatment with immunomodulator helped maximum children in recovery.