Background: Mental disorders are one of the most common disorders in the world and mental health is a major concern of public health in today society. Aim and objectives: To identify the relationship between history of childhood abuse and clinical profile of depressive disorders at adulthood in an Egyptian sample. Patients and methods: This was case control study conducted on 110 patients who had depressive disorders at the psychiatry outpatient clinic Suez Canal University Hospitals. Patients were divided into two groups: Group A: 55 Patients diagnosed with depressive disorders and history of childhood abuse and Group B: 55 Patients diagnosed with depressive disorders without history of childhood abuse (control group). Results: Emotional abuse in group A was statically significantly higher than in group B (p ˂ 0.001). Physical abuse in group A was statically significantly higher than in group B (p ˂ 0.001). Sexual abuse in group A was statically significantly higher than in group B (p ˂ 0.001). Emotional neglect in group A was statically significantly higher than in group B (p ˂ 0.001). And physical neglect in group A was statically significantly higher than in group B (p ˂ 0.001). Conclusion: Adults with history of childhood abuse either are more likely to have worse clinical profile of depressive disorders during their adulthood than adults without.