This study was conducted to assess the Clinical Profile of Patients Presenting with Acute Myocardial Infarction in a known population. Material and methods: The study was conducted on patients presenting with their first AMI. Patients presenting with their first ST-elevation myocardial infarction (STEMI) within 1 week were included in the study. Each patient was interviewed and encouraged to relate freely the circumstances surrounding the onset of the infarction event. Statistical analysis was conducted using SPSS software. Results: In this study, out of 100 subjects, 25 were males and 75 were females. Chest pain was the most common manifestation of myocardial infarction accounting for 59 subjects. Hypertension was the most common risk factor for this condition followed by diabetes and smoking. Conclusion: Chest pain was the most common manifestation of myocardial infarction. Hypertension was the most common risk factor for this condition followed by diabetes and smoking.