Since ancient times in China, ginseng has been a valuable natural Chinese medicinal material. Ginseng has the ability to replenish vitality, stimulate the spleen, increase blood circulation, sooth the nerves and enhance the sleep quality etc. It is well-liked among the wider populace as a health care product, and it operates well as a medicine to treat diseases in sufferers. As the main active substance of ginseng, ginsenoside has the effect of inhibiting tumor cell metastasis, improving immunity and promoting blood circulation. Ginsenoside Rg3 is currently a hot spot in the field of medical research, and a large number of anti-tumor mechanisms have been confirmed. This article summarizes the analysis of the anti-tumor therapeutic effect of ginsenoside Rg3 in the treatment of breast, lung, liver, gastric and colon cancer by reading a large number of papers in recent years. The research on the ginsenoside Rg3 chemical components and its anti-tumor pharmacological properties was reviewed. This paper summarizes the research of ginsenoside Rg3 on the treatment of various tumors, offers the theoretical foundation for further study as well as the basis for the drug's comprehensive development and use which supports the advancement of traditional Chinese medicine.