A wound may be defined as the disruption of cellular and anatomical continuity of the soft part of body structures caused by violence or trauma. Healing of wounds is one of the important areas of clinical medicine explained in many Ayurveda texts under the heading "Vrana Ropana". Vrana and its management have been dealt with since the Vedic period to the current era. Thus, it is a major problem right from the early stages of medical study. Despite brilliant advancements in surgery, wound management is still a subject of speculation. The Present study consists of a Clinical Study of Prapaundrikadi Ghrita in patients of Suddha Vrana. This study is an interventional, randomized parallel group clinical trial with Ayurveda and Allopathic system intervention. In the present study, patients with clean wounds were registered from OPD/IPD of the Department of Shalya Tantra, Sir Sunder Lal Hospital BHU Varanasi, and were divided into two groups, Patients of both groups were cleaned & dressed daily & all the selected criteria were assessed on day 0,7,14 and 28 based on Bates Jensen Wound Assessment tool. Prapaundrikadi Ghrita is one of those formulations which is described in Chakradutta, Bhaisajya Ratnawali, and Sushruta Samhita for the management of the wound and abscess. The feedback data of the clinical trials and observations have been noted with the reduction in signs and symptoms according to the Bates Jensen wound assessment tool along with, the effect of the therapy and statistical analysis during the study.