Osteoarthritis is one of the most frequent cause for pain and stiffness in the knee joints and it affects more post-menopausal Women. Chronic knee pain, painful movement are the major symptoms. Homeopathic medicines can provide more effective and long-lasting relief to the patients and thus providing an affordable and effective way of treatment. Homeopathy considers osteoarthritis as a chronic disorder of chronic miasmatic origin hence the treatment is to be given should remove the miasmatic block to cure the disease which is possible with the individualization after considering both mental and physical aspects of the patient. Methods: It is an interventional clinical study conducted at the outpatient department of Bharati Vidyapeeth (Deemed to be University) Homoeopathic College & Research Centre, Pune. Total 32 patients (Female Postmenopausal women) belonging to the age group of 45-65 years were enrolled in this study. Out of which, 02 patients dropped out and 30 patients completed their follow up. Osteoarthritis symptoms severity, pain & intensity was checked according to the assessment criteria of WOMAC osteoarthritis index Scale of symptoms was recorded. The study cases were selected purposively as per inclusion and exclusion criteria and diagnosis based on clinical presentation. Results: Total 32 cases were selected for the study. At the end of study it was observed that 28 cases improved, 2 cases not improved, 2 dropped out. WOMAC Score was < 60 in all improved cases after prescribing suitable Homeopathic medicines. Conclusion - The study found that homeopathic constitutional medicine treatments are more helpful in osteoarthritis patients, particularly in post-menopausal women, as majority of the patients were found to have improved with the signs and symptoms .WOMAC score also reduced after suitable Homeopathic remedies . Homoeopathic treatment decreased the severity of symptoms and consequently benefited the patient as a whole. Homoeopathy is a system of medicine that treats the body as a whole and enhances one's quality of life, not only cure the disease and its complications, but also bring the sick person back to optimal health.